Molecular Neurodegeneration

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Network analysis of the cerebrospinal fluid proteome reveals shared and unique differences between sporadic and familial forms of amyotrophic lateral sclerosis

Authors: Adam N. Trautwig, Edward J. Fox, Eric B. Dammer, Anantharaman Shantaraman, Lingyan Ping, Duc M. Duong, Caroline M. Watson, Fang Wu, Seneshaw Asress, Qi Guo, Allan I. Levey, James J. Lah, Federico Verde, Alberto Doretti, Antonia Ratti, Nicola Ticozzi…

Content type: Research 15 May 2025
Mouse models of Anti-Aβ immunotherapies

Authors: Philip Pikus, R. Scott Turner and G. William Rebeck

Content type: Review 13 May 2025
Cellular and molecular mechanisms of pathological tau phosphorylation in traumatic brain injury: implications for chronic traumatic encephalopathy

Authors: Neil Donison, Jacqueline Palik, Kathryn Volkening and Michael J. Strong

Content type: Review 10 May 2025
Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis

Authors: John Hardy and Patrick Lewis

Content type: Perspective 9 May 2025
Cautions on utilizing plasma GFAP level as a biomarker for reactive astrocytes in neurodegenerative diseases

Authors: Wongu Youn, Mijin Yun, C. Justin Lee and Michael Schöll

Content type: Perspective 9 May 2025

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The gut microbiome in Alzheimer’s disease: what we know and what remains to be explored

Targeted degradation of ⍺-synuclein aggregates in Parkinson’s disease using the AUTOTAC technology

The era of cryptic exons: implications for ALS-FTD

Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease

Translational molecular imaging and drug development in Parkinson’s disease

Plasma phospho-tau in Alzheimer’s disease: towards diagnostic and therapeutic trial applications

Common mouse models of tauopathy reflect early but not late human disease

Anti-amyloid therapies for Alzheimer disease: finally, good news for patients

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium

Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins

Aims and scope

Molecular Neurodegeneration (MN) is an open access, peer-reviewed journal dedicated to publishing groundbreaking research in the field of neurodegeneration. Our mission is to foster a deeper understanding of neurodegenerative diseases, including but not limited to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, glaucoma, and macular degeneration, to inform novel diagnosis and effective therapy. We aim to publish innovative studies addressing the complex mechanisms of neurodegenerative disorders at the molecular, cellular, and systems levels, with a strong emphasis on broad impact and scientific rigor.

Sister Journal

Molecular Neurodegeneration is sister journal to MN Advances, a journal dedicated to advancing research on neurodegeneration at the molecular, cellular, and systems levels.