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Figure 2 | Molecular Neurodegeneration

Figure 2

From: PrPScaccumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases

Figure 2

Immunohistochemical localization of PrPSc in neurons of the neocortex in Syrian hamsters inoculated with the Sc237 prion strain. A. A neuron in layer 4 of the neocortex at 42 days postinoculation (dpi) shows the plasma membrane filled with PrPSc. Peroxidase immunohistochemistry with the PrP-specific 3F4 monoclonal antibody. B. Three neurons at 58 dpi show early endosomal, late endosomal, and lysosomal staining for PrPSc (green). Goat polyclonal IgG against Cat D (red) was obtained from Santa Cruz Biosciences. Nuclei are stained blue. See text for explanation. Bars in A represents 10 μm and in B, 5 μm.

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Molecular Neurodegeneration

ISSN: 1750-1326