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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins

Fig. 2

Circular Manhattan Plots of brain AD-related protein GWAS. Circular Manhattan plots for each protein measured in three biochemical fractions. Plots for proteins with SNPs that reach genome-wide significance (GWS) are shown. Red dotted line marks GWS threshold of p-value = 2.98E-08, solid blue line marks p-value = 1E-05. Top SNPs at GWS loci have dots increased in size and labeled with the closest gene name. SNPs with a p-value <1E-05 are colored red. Radial axes measure -log10(P-value). Inner most blue circle is the soluble TBS fraction, middle green circle is the membrane TX fraction and outer most purple circle is the insoluble FA fraction

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Molecular Neurodegeneration

ISSN: 1750-1326