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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Microglial APOE4: more is less and less is more

Fig. 1

A schematic representation of the complementary gain-of-function and loss-of-function approaches used to examine the impact of human APOE on microglial function in AD. APOE4+/+ restricts microglia in a non-responsive state (left part of the circle), resulting in exacerbated amyloid pathology (red) and dystrophic neurites (green). In contrast, deletion of APOE4 in microglia rescues these deficits (right part of the circle)

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Molecular Neurodegeneration

ISSN: 1750-1326