Fig. 1

Regional Hyperphosphorylated Tau Pathology in CTE. Photomicrographs of AT8 immunostained cortical neurofibrillary tangles (NFTs), neurites, and astrocytic inclusions around small central vessels within the depths of sulci in a 71- year-old former professional American football player with stage IV CTE in the dorsolateral frontal cortex (a), inferior frontal cortex (b), inferior parietal cortex (c), superior temporal cortex (d), globose NFTs and neurities in the locus coeruleus (e), NFTs in the CA1 (f), CA2 (g) CA4 (h) hippocampal subfields, NFTs and neurites in the entorhinal cortex (i) layer 4 and basal nucleus of the amygdala (j). Scale bar = 100μm