Fig. 6
Treatment with ASO’s targeting APOE and TREM2 does not affect amyloid burden in APPNL−G−F mice. A Representative images of immunofluorescent analysis of amyloid plaques. Plaques were visualized with X-34. Scale bar represents 500um. B-C Quantification of X34-stained amyloid plaques; plaque numbers (B), total plaque volume (C) and average plaque size D was analyzed. E–G Levels of Ab40 (E) and Ab42 (F), and Ab42/40 (G) ratio in PBS-soluble fraction of brain homogenates. H-J Levels of Ab40 (H) and Ab42 (I), and Ab42/40 (J) ratio in guanidine-soluble fraction of brain homogenates. Bars represent mean ± SEM, n = 4/group