Fig. 1

General theme of ferroptosis. Ferroptosis is an iron-dependent cell death that disrupts the integrity of cell membranes. Lipid peroxidation is the executer of ferroptosis with three main prerequisites: high levels of reactive oxygen species (ROS) and redox labile iron and compromised lipid peroxide repair systems. LOO●: lipid peroxides, LOOH●: lipid hydroperoxides