Fig. 7

LRRK2 protein levels predict pT73-Rab10 levels that are elevated in PD cases with worse MDS-UPDRS scores. (A) Scatter plots show relationships between measured serum levels of total Rab10 and LRRK2, (B) pT73-Rab10 and LRRK2, and (C) the ratio of pT73-Rab10 to Rab10 and LRRK2. N = 522 cases and controls (see Table 1). R values show correlation coefficients and p values correspond to mean linear regression analysis of lines (red) with 95% confidence intervals shown (red dashed curves). (D) Box and whisker plot comparing the mean MDS-UPDRS part III scores in PD cases split to lower (< 0.5) and higher (> 0.5) ratios of pT73-Rab10/Rab10. P value indicated is from a Mann-Whitney U test for comparisons of groups with unequal sizes