Table 1 Demographics, clinical information, and biomarker data in subjects recruited into the Parkinson’s disease biomarker program (PDBP)
Male (N = 276) | Female (N = 246) | |||||
|---|---|---|---|---|---|---|
Cohort feature | PD (N = 187) | HC (N = 89) | p* | PD (N = 90) | HC (N = 156) | p* |
Disease duration, Mean years (SD) | 8.1 (5.9) | 0 | < 0.0001 | 6.5 (4.5) | 0 | < 0.0001 |
Age, Mean years (SD) | 64.0 (9.6) | 61.0 (13.2) | 0.259 | 63.9 (8.8) | 59.6 (9.9) | 0.001 |
MDS-UPDRS I, Mean (SD) | 10.8 (5.9) | 5.1 (4.5) | < 0.0001 | 11.8 (6.1) | 5.4 (4.0) | < 0.0001 |
MDS-UPDRS II, Mean (SD) | 14.6 (8.1) | 1.3 (2.6) | < 0.0001 | 12.8 (8.3) | 0.9 (2.1) | < 0.0001 |
MDS-UPDRS III, Mean (SD) | 29.1 (13.4) | 0.3 (1.0) | < 0.0001 | 24.5 (11.1) | 0.2 (0.7) | < 0.0001 |
MDS-UPDRS IV, Mean (SD) | 1.8 (3.2) | 0 | < 0.0001 | 1.9 (2.9) | 0 | < 0.0001 |
MDS-UPDRS Total, Mean (SD) | 56.4 (24.2) | 6.9 (6.8) | < 0.0001 | 50.9 (21.1) | 6.4 (5.7) | < 0.0001 |
MoCA, Mean (SD) | 24.0 (3.5) | 25.5 (3.0) | 0.001 | 25.1 (3.0) | 27.1 (1.9) | < 0.0001 |
UPSIT, Mean (SD) | 18.3 (7.3) | 30.9 (6.0) | < 0.0001 | 20.4 (8.1) | 34.3 (4.1) | < 0.0001 |
Epworth Sleep Scale, Mean (SD) | 9.9 (4.7) | 6.6 (3.6) | < 0.0001 | 9.1 (5.2) | 5.2 (3.2) | < 0.0001 |
NSAID use, N (%) | 84 (45) | 28 (31) | 0.036 | 36 (40) | 46 (29) | 0.095 |
Statin use, N (%) | 60 (32) | 31 (35) | 0.682 | 25 (28) | 40 (26) | 0.765 |
LEDD, Mean (SD) | 561 (500) | 0 | < 0.0001 | 513 (757) | 0 | < 0.0001 |
Family history of PD, N (%) | 49 (26) | 7 (8) | 0.0003 | 27 (30) | 9 (6) | < 0.0001 |
Serum biomarkers and characteristics | ||||||
Sample days-in-freezer, Mean (SD) | 2214 (364) | 2240 (338) | 0.671 | 2296 (335) | 2184 (344) | 0.007 |
Total LRRK2, ng/mL, Median (IQR) | 0.77 (2.04) | 0.50 (1.40) | 0.034 | 0.49 (2.43) | 0.50 (1.16) | 0.318 |
Mean 95%CI [LL, UL] | 12.05 [-1.93, 26.02] | 4.36 [2.08, 6.65] | 3.24 [1.87, 4.63]) | 3.07 [1.33, 4.81] | ||
pT73-Rab10, ng/mL, Median (IQR) | 1.09 (8.81) | 0.68 (5.77) | 0.252 | 1.19 (9.45) | 0.28 (2.36) | 0.073 |
Mean 95%CI [LL, UL] | 17.36 [7.00, 27.72] | 11.83 [5.59, 18.07] | 8.69 [5.03, 12.35] | 5.70 [3.49, 7.91] | ||
Rab10, ng/mL, Median (IQR) | 7.69 (40.67) | 8.01 (25.46) | 0.491 | 10.51 (47.12) | 5.68 (12.65) | 0.012 |
Mean 95%CI [LL, UL] | 115.45 [60.99, 169.90] | 66.22 [29.69, 102.75] | 68.24 [38.00, 98.48] | 45.77 [23.31, 68.23] | ||
pT73-Rab/Rab10, %, Median (IQR) | 10.1 (23.8) | 8.8 (20.57) | 0.260 | 7.2 (17.8) | 6.2 (14.2) | 0.452 |
Mean 95%CI [LL, UL] | 17.6 [14.5, 20.7] | 15.2 [10.8, 19.6] | 14.2 [10.3, 18.2] | 12.6 [9.6, 15.6] | ||