From: Single-cell peripheral immunoprofiling of Lewy body and Parkinson’s disease in a multi-site cohort
HC n = 159 | AD n = 97 | LBD n = 110 | NDC n = 19 | IDC n = 14 | Overall P* Pairwise | |
---|---|---|---|---|---|---|
Age | ||||||
Mean (SD) | 73.0 (6.0) | 74.8 (8.0) | 72.2 (7.2) 52- | 73.4 (6.9) | 67.2 (3.3) 63 | 0.002 |
Range | 55–95 | 51–91 | 92 | 67—84 | - 74 | AD, HC > IDC |
Gender | ||||||
N (%) Female | 90 (56.6%) | 57 (58.8%) | 50 (45.5%) | 12 (63.2%) | 10 (71.4%) | 0.147 |
Race N (%) | N = 156 | N = 95 | N = 105 | |||
White | 126 (80.8%) | 84 (88.4%) | 99 (94.3%) | 16 (84.2%) | 13 (92.9%) | 0.123 |
Black | 2 (1.3%) | 1 (1.1%) | - | 1 (7.1%) | ||
American Indian/Alaskan Native | 1 (0.6%) | - | 1 (1.0%) | - | - | |
Native Hawaiian/Pacific Islander | - | - | - | - | - | |
Asian | 25 (16.0%) | 9 (9.5%) | 5 (4.8%) | - | - | |
Other/mixed race | 2 (1.3%) | 1 (1.1%) | - | 3 (15.8%) | - | |
Education | N = 95 | N = 105 | N = 18 | |||
Mean (SD) | 16.9 (2.3) | 15.8 (3.2) | 17.1 (2.3) | 16.4 (3.5) | - | 0.003 |
Range | 12—22 | 8—24 | 12—20 | 8—23 | LBD, HC > AD | |
Cognitive status N (%) | N = 158 | N = 96 | N = 103 | - | ||
No cognitive impairment | 162 (100.0%) | - | 55 (53.4%) | 9 (47.4%) | LBD vs. NDC: | |
CIND | - | - | 30 (29.1%) 18 (17.5%) | 4 (21.1%) | 0.399 | |
Dementia | - | 96 (100.0%) | 6 (31.6%) | |||
Use of AD medications | N = 105 | < 0.0001 | ||||
N (%) | - | 64 (66.0%) | 20 (19.1%) | 3 (15.8%) | - | AD > LBD, NDC |
Use of PD medications | N = 63 | N = 91 | < 0.0001 | |||
N (%) | - | 3 (4.8%) | 80 (87.9%) | 3 (15.8%) | - | LBD > AD, NDC |