Skip to main content

Table 1 Cohort statistic summary stratified by diagnosis groups

From: Single-cell peripheral immunoprofiling of Lewy body and Parkinson’s disease in a multi-site cohort

 

HC

n = 159

AD

n = 97

LBD

n = 110

NDC

n = 19

IDC

n = 14

Overall P*

Pairwise

Age

 Mean (SD)

73.0 (6.0)

74.8 (8.0)

72.2 (7.2) 52-

73.4 (6.9)

67.2 (3.3) 63

0.002

 Range

55–95

51–91

92

67—84

- 74

AD, HC > IDC

Gender

      

 N (%) Female

90 (56.6%)

57 (58.8%)

50 (45.5%)

12 (63.2%)

10 (71.4%)

0.147

Race N (%)

N = 156

N = 95

N = 105

   

 White

126 (80.8%)

84 (88.4%)

99 (94.3%)

16 (84.2%)

13 (92.9%)

0.123

 Black

2 (1.3%)

1 (1.1%)

-

 

1 (7.1%)

 

 American Indian/Alaskan Native

1 (0.6%)

-

1 (1.0%)

-

-

 

 Native Hawaiian/Pacific Islander

-

-

-

-

-

 

 Asian

25 (16.0%)

9 (9.5%)

5 (4.8%)

-

-

 

 Other/mixed race

2 (1.3%)

1 (1.1%)

-

3 (15.8%)

-

 

Education

 

N = 95

N = 105

N = 18

  

 Mean (SD)

16.9 (2.3)

15.8 (3.2)

17.1 (2.3)

16.4 (3.5)

-

0.003

 Range

12—22

8—24

12—20

8—23

 

LBD, HC > AD

Cognitive status N (%)

N = 158

N = 96

N = 103

 

-

 

 No cognitive impairment

162 (100.0%)

-

55 (53.4%)

9 (47.4%)

 

LBD vs. NDC:

 CIND

-

-

30 (29.1%) 18 (17.5%)

4 (21.1%)

 

0.399

 Dementia

-

96 (100.0%)

 

6 (31.6%)

  

Use of AD medications

  

N = 105

  

 < 0.0001

 N (%)

-

64 (66.0%)

20 (19.1%)

3 (15.8%)

-

AD > LBD, NDC

Use of PD medications

 

N = 63

N = 91

  

 < 0.0001

 N (%)

-

3 (4.8%)

80 (87.9%)

3 (15.8%)

-

LBD > AD, NDC

  1. Abbreviations: AD Alzheimer’ disease, CIND Cognitively impaired, but not dementia, HC healthy controls, IDC immune disease controls, LBD Lewy body disease, NDC neurodegenerative disease controls, PD Parkinson’s disease
  2. *P values based on one way ANOVA for continuous variables and chi-square or Fisher’s exact tests for categorical variables