Fig. 6
From: Heparin-enriched plasma proteome is significantly altered in Alzheimer’s disease
Evaluation of heparin-enriched plasma proteins for classifying AD. ROC curves for CSF biomarker confirmed AD (n = 61) versus biomarker-negative control individuals (n = 34) were generated to determine the top-ranked diagnostic proteins among the 536 highly significant plasma proteins (meta p < 0.0001) with no missing values across all unique 95 individuals. A Individual ROC curves and AUCs for the top ten ranked plasma proteins, as well as plasma pTau181 alone. B ROC curves and AUCs of i) the combined top five performing proteins as a panel (pink), ii) plasma pTau181 alone (green), and iii) plasma pTau181 plus the protein panel (blue). ROC curve statistics for highly significant proteins, including AUC, p-value, 95% DeLong confidence interval, accuracy, specificity, and sensitivity for AD vs CTL, are provided in Supplemental Table 27. CTL, control; AUC, area under the curve