Fig. 4
From: Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease
Differential gene expression analysis and GO pathway analysis of OLs inBace1fl/fl, Bace1fl/fl;Olig2-Cre, Bace1fl/fl;Olig2-Cre; AppNL−G−F/wtandBace1fl/fl;AppNL−G−F/wtmice. (A, C) Volcano plot depicting myelin genes labeled in red were differentially expressed in the oligodendrocytes of Bace1fl/fl;Olig2-Cre compared to Bace1fl/fl mice in (A) and Bace1fl/fl;Olig2-Cre; AppNL−G−F/wt mice compared to Bace1fl/fl;AppNL−G/wt mice in (C). (B, D) GO biological process enrichment analyses of up-regulated and down-regulated genes in the oligodendrocytes of Bace1fl/fl;Olig2-Cre mice compared to Bace1fl/fl mice in (B) and of Bace1fl/fl;Olig2-Cre; AppNL−G−F/wt mice compared to Bace1fl/fl;AppNL−G/wt mice in (D). (E) Dot plots show that the average gene expression of ADAM10, Ano4, ApoE, Il33, and Sort1 increased in the oligodendrocytes of Bace1fl/fl;Olig2-Cre; AppNL−G−F/wt mice compared to other genotypes. (F-G) Immunoblot and quantification showing the level of ADAM10 increased in Bace1fl/fl;Olig2-Cre; AppNL−G−F/wt mice compared to Bace1fl/fl;AppNL−G−F/wt mice. N = 3 independent experiments, **P < 0.01, two-tailed Student t-test