Fig. 6
From: Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease
Oligodendrocyte Bace1 deletion has differential effects on central or peripheral myelination. (A) Immunoblot analysis of PLP and MBP in 4-month-old Bace1fl/fl and Bace1fl/fl;Olig2-Cre hippocampi. Antibody to β-actin was used as loading control. (B) Bar graph shows quantification of relative protein levels based on the blot shown in A. N = 3 independent experiments, two-tailed Student’s t test. Values are expressed as mean ± SD. (C-E) Representative images of myelinated axons (C) in the corpus callosum and the scatter plot (D, n = 2 mice) as well as bar graph (E) against axonal diameter of the g-ratios of myelinated axons in all four groups. (F-H) Representative images (F) of myelinated axons in the optic nerves and bar graph (G) against axonal diameter of the g-ratios of myelinated axons in all four groups. The scatter plot is also presented (H, N = 2 mice in each genotype). Scale bar, 1 μm; axonal numbers are indicated in parenthesis; ***P < 0.001