Fig. 5
From: Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB
VCP mutant microglia share microglial gene expression changes with SOD1 mutant mice and post-mortem ALS spinal cords. A Scatterplot of the differential gene expression z-statistical (Wald test) between VCP mutant microglia (x-axis) and microglia from SOD1 mutant mice (y-axis). B Venn diagram showing overlap of differentially expressed genes (FDR < 0.05) between VCP mutant microglia and SOD1 mutant mouse microglia. C Scatterplot of differential gene expression z-statistical (Wald test) between VCP mutant (x-axis) and post-mortem ALS spinal cord (y-axis). D Scatterplot of differential gene expression z-statistical (Wald test) between VCP mutant (x-axis) and microglia M17 module (y-axis) from post-mortem ALS spinal cord. E Heatmap showing the Pearson’s correlation coefficient for transcriptome-wide changes between each post mortem ALS genetic background and VCP mutant microglia. F Venn diagram of differentially expressed genes (FDR < 0.05) between VCP mutant microglia and post-mortem ALS spinal cord. G GO terms enriched in co-upregulated differentially expressed genes in VCP mutant microglia and post-mortem ALS spinal cord. H Gene set enrichment analysis for lysosomal lumen genes in ALS spinal cord