Fig. 5
From: VCP regulates early tau seed amplification via specific cofactors
VCP inhibition impacts tau seeding early in the process. A Timeline of compound and tau treatments at different time points in the seeding process. B ML-240 increased tau aggregation ~ 16 to 25-fold, but only when administered < 8 h after seed exposure. Representative images are shown in the right panel. Scale bar = 50 μm. P values: **** < 0.0001, ns (16hr) = 0.5892, ns (24hr) = 0.4340, ns (48hr) = 0.3569. (C) NMS-873 decreased tau seeding by ~50%, but only when administered <8h after seed exposure. Representative images are shown in the right panel. Scale bar = 50μm. P values: ** 0.0039, *** 0.0004, ns (16hr) = 0.0788, ns (24hr) = 0.8695, ns (48hr) = 0.0547. Error bars represent S.D. Representative data of n=3 independent experiments, with each data point derived from technical triplicate. One-Way ANOVA with a 95% confidence interval