Fig. 7
From: VCP regulates early tau seed amplification via specific cofactors
ML-240 enhances seeding by human brain lysates. A ML-240 increased seeding by AD and CBD brain samples onto v2L P301S tau biosensors and (B) by AD brain sample onto WT tau (3R/4R) biosensors. C ML-240 increased seeding of FTLD type A brain lysate onto TDP-43 biosensors. Error bars represent S.D. Representative data of n = 3 independent experiments, with each data point derived from technical triplicate. P value: **** < 0.0001, *** 0.0008; One-Way ANOVA with a 95% confidence interval. D Representative microscopy images showing effects of ML-240 on tauopathy lysates and TDP-43 seeding. Scale bar = 50 μm