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Table 3 Description and mode of action for inhibitors of protein degradation pathways and muscarinic receptors

From: Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons

No.

Name

Function

1

Bafilomycin A1 (Baf)

An inhibitor of vacuolar ATPase that prevents lysosomal acidification, inhibiting the activation of lysosomal proteases (55)

2

Chloroquine (CQ)

An inhibitor of autophagic flux by blocking the fusion of autophagosomes with lysosomes (56)

3

MG132

An inhibitor of proteasome activity by blocking the proteolytic activity of the 26 S proteasome complex (57)

4

Atropine (Atr)

A non-selective antagonist of the muscarinic receptor that inhibits Tau uptake (58)

5

Pirenzepine (Pirz)

An antagonist of the M1 muscarinic receptor that inhibits Tau uptake (58)

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Molecular Neurodegeneration

ISSN: 1750-1326