Fig. 7
From: Microglial CD2AP deficiency exerts protection in an Alzheimer’s disease model of amyloidosis
Microglial CD2AP haploinsufficiency reverses increased C1q expression in 5xFAD mice. A mRNA levels of C1qa, C1qb, and C1qc relative to those of Gapdh in the hippocampus of 7-month-old Cd2apfl/+ (n = 4), Cx3cr1-cre (n = 4), Cd2apfl/+;Cx3cr1-cre (n = 4), 5xFAD;Cd2apfl/+ (n = 4), 5xFAD; Cx3cr1-cre (n = 3), and 5xFAD;Cd2apfl/+;Cx3cr1-cre (n = 3) mice were determined for comparison. 1-way ANOVA followed by Dunnett’s post hoc test. B C1q protein levels in the hippocampus of 7-month-old mice with different genotypes were analyzed by western blot and quantified for comparison. n = 4 mice per genotype. 1-way ANOVA followed by Tukey’s post hoc test. Data are presented as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; ns, not significant