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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands

Fig. 1

Structure-guided TREM2 variants created to map interactions with ligands. (A) Schematic of TREM2 receptor on surface of microglia, and TREM2 versions described in this manuscript. (B) Ribbon diagram of TREM2 showing location of residues mutated, colored coded by site (red = hydrophobic; blue = basic; gray = basic adjacent; orange = site 2. (C) Table of all TREM2 variants produced for this manuscript or in our previous publications

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Molecular Neurodegeneration

ISSN: 1750-1326