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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands

Fig. 7

TREM2 basic site variants centered around R76 inhibit binding to IL-34. Immobilized TREM2 was probed for binding to IL-34 (62.5–1000 nM). (A) Scheme of experiment. (B-N) BLI sensorgrams for IL-34 binding to TREM2 (B) WT, (C) R47H, (D) D87N, (E) T96K, (F) R46D, (G) W44D/L69D/L71D, (H) L69D/L71D, (I) R62H, (J) R76D, (K) R77D, (L) W78D, (M) L75D, (N) T85D, (O) R122E, (P) R122D/K123D. Black = BLI sensorgrams; red = 1:1 kinetic fits. Results shown in Table 3

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Molecular Neurodegeneration

ISSN: 1750-1326