Table 1 TREM2 variants binding to apoE4

WT

281 ± 43*

-

R47H

643 ± 91*

↓ 2.29

R62H

561 ± 117*

↓ 2.00

D87N

25 ± 6

↑ 11.24

T96K

891 ± 196*

↓ 3.17

M41D

1426 ± 566*

↓ 5.07

W44D

2565 ± 710*

↓ 9.12

L69D

55,060 ± 20,390*

↓ 195.94

W70D

28,110 ± 14,380*

↓ 100.04

F74D

9709 ± 1163*

↓ 34.55

L69D/L71D

N.B.D.**

-

W44D/L69D/L71D

N.B.D.**

-

R76D

1529 ± 693

↓ 5.44

R77D

1659 ± 379

↓ 5.90

R46A/R47A

388 ± 141

↓ 1.38

R122D/K123D

120 ± 22

↑ 2.30