Table 3 TREM2 variants binding to IL-34
TREM2 variant | KD (nM) | Fold decrease vs. WT |
|---|---|---|
WT | 16.5 ± 0.2 | - |
R47H | 79.8 ± 2.4 | ↓4.8 |
R62H | 75 | ↓4.5 |
D87N | 28.4 ± 0.5 | ↓1.7 |
T96K | 23.7 ± 0.4 | ↓1.4 |
R46D | 18.0 ± 0.3 | ↓1.1 |
R76D | N.B.D | - |
R77D | 114 ± 4 | ↓6.9 |
L75D | 36.6 ± 0.9 | ↓2.2 |
W78D | 17.2 ± 0.4 | ↓1.04 |
T85D | 21.5 ± 0.6 | ↓1.3 |
R122E | 29.4 ± 0.4 | ↓1.8 |
R122D/K123D | 18.5 ± 0.3 | ↓1.1 |
L69D/L71D | 20.2 ± 0.3 | ↓1.2 |
W44D/L69D/L71D | 25.8 ± 0.3 | ↓1.6 |