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Table 2 Cell-type specific expression patterns of transmembrane receptors and proteins in the human brain

From: Emerging targets of α-synuclein spreading in α-synucleinopathies: a review of mechanistic pathways and interventions

 

Neurons (nPTM)

Astrocytes (nPTM)

Microglial cells (nPTM)

Oligodendrocytes (nPTM)

Oligodendrocyte precursor cells (nPTM)

All cell types (nPTM)

LRP1

37.77 (26.1–55)

107.8

85.9

5.25

162.7

399.42

LAG3

0.16 (0-0.9)

0

0

0

0

0.16

APLP1

53.05 (21.5-120.5)

11.8

11.6

402.45

17.9

496.8

TLR4

0.20 (0-1.3)

48.3

25

0.3

7.1

80.9

α3-NKA

76.62 (17.9-159.9)

8.7

8.1

11.05

13.7

69.28

Integrin CD11b

0.97 (0.5–2.3)

0.6

39.4

0.4

2.8

44.17

FcγRIIB

0

0

0

0.05

0

0.05

HSPG

1.02 (0.3–4.8)

3.4

15.2

3.25

2.4

25.27

PrPc

135.8 (73.1-229.7)

113.9

56.4

133.4

89.1

528.6

GPNMB

0.63 (0-3.6)

0.3

11.6

0.1

52.4

65.03

  1. Cell-type specific expression levels of cell surface receptors and membrane proteins quantified in normalized protein transcript metric (nPTM). Data acquired from The Human Protein Atlas (proteinatlas.org) [56].