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Table 4 Targeting pathological agents

From: Emerging targets of α-synuclein spreading in α-synucleinopathies: a review of mechanistic pathways and interventions

Target

Function

Mechanism

Intervention

 

SNCA gene

Encodes for α-syn

Introduces α-syn at the genetic level

Silencing α-syn through RNAi, miRNA, and ASOs

[132, 133, 136, 138,139,140,141]

α-Syn oligomers

Neurotoxic protein aggregates of monomers

Induces α-syn pathology and further aggregation into PFFs

Inhibit aggregation and spread through small molecules

[129, 130, 148]

α-Syn fibrils

Aggregated neurotoxic insoluble protein complex

Induces α-syn pathology

Inhibit spreading and internalization through small molecules, antibodies, and nanobodies; active immunization

[131, 146, 147, 149, 154, 156, 163, 165, 167, 170, 171, 173, 174]

  1. Targeting pathological agents as targets for α-syn-induced pathology and their respective intervention techniques
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Molecular Neurodegeneration

ISSN: 1750-1326