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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Cell-specific transcriptional signatures of vascular cells in Alzheimer’s disease: perspectives, pathways, and therapeutic directions

Fig. 2

Dysregulated pathways identified by single cell RNA analysis of the human cerebrovascular cells. Red and blue arrows denote upregulated and downregulated transcriptomic pathways in AD, respectively. Angiogenesis and immune response are strongly associated and upregulated in endothelial and mural cells, whereas machinery supporting synaptic transmission, cytoskeletal remodeling, and BBB regulation show possible downregulation in response to AD. Figure created with BioRender.com. Abbreviations: NVU, Neurovascular unit; BEC, brain endothelial cells; CNS, Central Nervous System; BBB, Blood–brain barrier

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Molecular Neurodegeneration

ISSN: 1750-1326