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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Cell-specific transcriptional signatures of vascular cells in Alzheimer’s disease: perspectives, pathways, and therapeutic directions

Fig. 3

Cellular crosstalk is altered at the NVU and GVU during AD. Evidence of impaired ligand-receptor communications between astrocytes and endothelial as well as neurons and pericytes in AD (left). Pericytes and endothelial cells collectively show increased communication with the neuroglial unit, whereas fibroblast clusters show significantly decreased communication with astrocytes and neurons in AD. Figure created with BioRender.com. Abbreviations: AD, Alzheimer’s disease; NVU, Neurovascular unit; GVU: Gliovascular unit

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Molecular Neurodegeneration

ISSN: 1750-1326