Fig. 3
From: Srebf2 mediates successful optic nerve axon regeneration via the mevalonate synthesis pathway
Srebf2 loss-of-function inhibits axon regeneration in the optic tectum at 7 dpi. (A) Representative images of tectum and higher magnification of medial-ventral tectum of vehicle or fatostatin treated zebrafish. (B) Quantification of tectum regeneration at dorsal, medial, and ventral region after srebf2-MO1 treatment. (C) Quantification of tectum regeneration at dorsal, medial, and ventral region after srebf2-MO2 treatment. (D) Quantification of tectum regeneration at dorsal, medial, and ventral region post fatostatin treatment. Grey boxes indicate p < 0.05 compared with Ctrl MO or Vehicle at the corresponding rostral to caudal distance by two-way ANOVA with Fisher’s LSD post hoc test. Scale bar = 500 and 200 μm, n = 5–6 for each group