Fig. 8
From: Srebf2 mediates successful optic nerve axon regeneration via the mevalonate synthesis pathway
Axon regeneration into the optic tectum is dependent upon the mevalonate synthesis pathway. (A) Axon regeneration into the optic tectum is reduced upon hmgcra + hmgcrb knockdown (hmgcra + b-MO), rescued by daily supplementation with mevalonate (MVA), and accelerated by MVA treatment alone. (B) Quantification of axon regeneration in each treatment group. Colored boxes represent p < 0.05 in treated groups compared with the C-MO and/or Vehicle treated group in the corresponding column by two-way ANOVA with Fisher’s LSD post hoc test, n = 5–6 for each group. Scale bar = 500 μm