Fig. 1
From: 18F-MK-6240 tau PET in patients at-risk for chronic traumatic encephalopathy
3H-MK-6240 autoradiography, AT8 immunohistochemistry, and X-34 histology in a CTE Stage III case and an AD Braak NFT Stage VI case. 3H-MK-6240 autoradiography with (A, E, I) and without (B, F, J) cold compound block, AT8 immunohistochemistry (green; C–C’, G-G’, K-K’) and X-34 stain (blue; D-D’, H–H’, L-L’) on three adjacent 10 μm cryosections of superior temporal cortex (left column) and dorsolateral prefrontal cortex (middle column) from a case neuropathologically diagnosed as CTE Stage III, with Braak NFT Stage III and Thal-1 phase for amyloid-β (Case 6) and superior temporal cortex from an AD case with Braak NFT Stage VI (right column). Low power magnification images of AT8 (C, G, K) and X-34 (D, H, L) illustrate areas with high densities of labeled structures (marked by the red boxes in B, F, J). Panels C’, G’, K’ and D’, H’, L’ are higher magnifications of the areas delineated by the yellow boxes in C, G, K and D, H, L, respectively. FC = dorsolateral prefrontal cortex; TC = superior temporal cortex. Scale bars: 1 mm (A, B, E, F, I, J); 200 μm (C, D, G, H, K, L), 100 μm (C’, D’, G’, H’, K’, L’)