Table 1 Biofluids and tissues markers in iRBD
Technique | Biological Sample | Cost Invasiveness Sensitivity/specificity | Prodromal PD cross-sectional | Prodromal PD longitudinal |
|---|---|---|---|---|
Total αSyn | CSF | +/- + NA | - | - |
oligomeric αSyn (ELISA) | CSF Blood | +/- + NA +/- + NA | ++ NE | - NE |
RT-QuIC αSyn | CSF Saliva GI Biopsy Skin Olfactory Mucosa | + + +++/+++ +/- - NA + ++ -/- + +/- +++/+++ + +/- +/++ | ++ - ++ ++ + | + - - ++ - |
NfL | CSF Blood | NA - - ++/- | - ++ | - ++ |