Fig. 3
From: Mechanisms of astrocyte aging in reactivity and disease
Changes in cellular environments, including changing damage/inflammation signals and metabolic dysfunction, contribute to altered intracellular functions and maintenance of homeostasis in astrocytes. In turn, these dysfunctions are associated with worsened outcomes for neurons and other CNS cells, astrocytes lose their ability to provide supportive factors and potentially gain toxic functions. Figure made using Biorender.com