Fig. 1

DLB nuclear extracts are seed competent. a Thioflavin T fluorescence traces from seed amplification assay (SAA) of nuclear extractions from controls (Con) and dementia with Lewy body (DLB) cases (n = 4, per group). Mean trace per group ± SEM (dotted lines) is shown. b SAA products taken at 20, 60 120h of reaction time were quantified for oligomeric aSyn concentration as detected via Syn-O2 antibody ELISA. Data shown as scatter plot of aSyn oligomer concentration per disease group at relevant time points. Data shown as Mean ± SEM. Outcome of 2 way ANOVA shown in corresponding plots and significant Bonferroni post-test indicated. * = p < 0.05, ** = p < 0.01, **** = p < 0.0001