Fig. 6

Altered nuclear proteome of DLB temporal cortex tissue. a Upregulated, downregulated and unchanged nuclear proteins in temporal cortex of dementia with Lewy body cases (DLB), compared to controls (Con). Data provided as absolute numbers and percentages of total identified proteins. b Z-score heatmap of altered proteins between Con and DLBs. c Uniprot keyword enrichment of the 89 proteins established as elevated in nuclear proteome of DLB compared to controls. Fold enrichment and significance is shown as per false discovery rate for each individual keyword. Keywords are grouped into clusters as reported per the DAVID bioinformatic database. Dotted lines denote the boundaries of clusters, with cluster enrichment (C.Enrich) from background reference database shown within each cluster. d STRING map of protein interactome of upregulated proteins. Prominent functional category of “Cellular response to DNA damaging stimulus” is highlighted (red) with individual proteins associated with each term denoted by colour and hub of strong interaction associated highlighted by background colour. Physical and functional interactions are shown with the weighting of line indicating confidence in interactions. e STRING interaction map and f) Z-score heat map of upregulated proteins associated with “Cellular response to DNA damaging stimulus” plotted in isolation