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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement

Fig. 5

STMN2 cryptic exon detection in the context of pTDP-43 pathological stage and load. (a) pTDP-43 pathology stage classification for the 22 ALS patients examined by RNA-seq and their semi-quantitative pTDP-43 pathology load for four examined CNS regions. The pTDP-43 pathology load was missing for Case16 in the motor cortex. Detection of the STMN2 cryptic exon by: (b) pTDP-43 pathology stage group and (c) pTDP-43 pathology load. Only one read spanning the STMN2 cryptic exon junction (chr8:79611214:79616822) was required to be called as detected. The number of individuals within each group is shown to the right of the dotted line

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Molecular Neurodegeneration

ISSN: 1750-1326