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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer’s disease

Fig. 3

Scatterplots illustrating the interaction effect between global amyloid-PET (i.e. centiloid) and aSyn SAA status on tau-PET SUVRs for meta-ROIs (A-D) and regional analyses (E), as well as for annual tau-PET SUVR change rates (F-J). Diagnostic groups are indicated by shape, the cut-point of amyloid-PET positivity is indicated by the dashed red line at 25 centiloids. Beta values indicate the strength of the amyloid-PET x CSF αSyn SAA interaction effect, as determined by linear regression, controlling for age, sex and study site (A-E) as well as maximum tau-PET follow-up time (F-J). FDR-correction for multiple comparisons (p < 0.05) was applied for the main analyses (A, F), adjusting for five statistical tests. In addition, ROI-wise assessments were also FDR-corrected at p < 0.05

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Molecular Neurodegeneration

ISSN: 1750-1326