Fig. 6
From: A stress-dependent TDP-43 SUMOylation program preserves neuronal function
SUMOylation correlates with aging and is enriched in the prefrontal cortex of ALS/FTD patients. A Demographic composition of temporal lobe samples from aging cohort. B Representative western blot and box plot of SUMO2/3 across binned age groups. Average Age: “Young” = 6.32 yrs, N = 14; “Adult” = 31.11 yrs, N = 20; “Aged” = 64.00 yrs, N = 19. Kruskall-Wallis with Uncorrected Dunn’s multiple comparisons test. * p < 0.05, ** p < 0.005. C Representative images and quantification from proximity ligation assay (PLA) between SUMO2/3 and TDP-43 in the prefrontal cortex from 3 patients diagnosed with ALS/FTD and unaffected controls. (N = 7–8) Unpaired T-test. Data presented as mean PLA foci/per field of view ± SEM relative to average of unaffected controls, * p < 0.05