Fig. 2
From: Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease
Phenotype associations for the TYROBP deletion proxy marker rs1244787406-G. A Phenotype association study covering 2,489 endpoints indicates significantly increased risk for dementia and AD among carriers of rs1244787406 minor G allele. The dashed line represents genome-wide significance threshold P = 5 × 10−8. B-C Kaplan–Meier survival plots showing the proportion free from dementia (B) and AD (C) among rs1244787406-G carriers (purple line) and non-carriers (black line). Shading indicates 95% confidence intervals. X-axis indicates age at the first diagnosis for cases and age at the end of follow-up for controls. D Regional association plot of the TYROBP locus shows the negative log10-transformed P-values on the y axis for the endpoint ‘Dementia (including primary healthcare outpatient registry)’ derived from FinnGen. The vertical dashed line represents genome-wide significance threshold P = 5 × 10−8. Each dot represents an individual SNV, and the dot color represents LD with the LD reference variant (purple diamond). The dotted line in the upper panel delineates the area shown in the lower panel. The red vertical lines indicate the 5.2 kb TYROBP deletion break points while the shaded grey area represents the TYROBP deletion associated shared haplotype region in the lower panel