Fig. 4

Effect of the Finnish 5.2-kb TYROBP deletion on AD-related Aβ pathology. A A representative image of frontal cortex biopsy immunostained for microglia (Iba- 1, brown) and Aβ (red). Scale bar 50 µm. B-D Number (B) and size (C) of Aβ plaques, and the number of Aβ plaque-associated microglia (D) in immunohistochemical images shown in (A); n = 1–5 individuals per genotype. E Aβ42 levels in the CSF; n = 1–4 individuals per genotype. Data are shown as mean ± SD. Independent samples T-test for T^CV/A³³ and T^CV/A³⁴. *: P < 0.05. T^CV, TYROBP common variant; T^del, monoallelic TYROBP deletion; A³³, APOE ε3ε3; A.³⁴, APOE ε3ε4