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Table 3 Hazard ratios for dementia and Alzheimer’s disease endpoints in FinnGen cohort

From: Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease

 

Dementia, including primary healthcare outpatient registry

Alzheimer

 

HR

95% CI

p-value

HR

95% CI

p-value

rs1442787406

2.14

1.85–2.47

 < 2e- 16

2.59

2.16–3.11

 < 2e- 16

rs429358

2.30

2.25–2.34

 < 2e- 16

2.74

2.67–2.81

 < 2e- 16

sex

1.13

1.10–1.16

 < 2e- 16

1.07

1.04–1.11

 < 2e- 16

  1. The model includes TYROBP deletion proxy marker rs1442787406, APOE ε4 allele rs429358 and sex
  2. CI Confidence interval, HR Hazard ratio
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Molecular Neurodegeneration

ISSN: 1750-1326