Fig. 6

TMEM106B overexpression alters synaptic transmission in the hippocampus. A Graphical representation of the experimental set-up. We performed electrical stimulation of the Schaffer collateral pathway in the hippocampal CA1 region of 12-month-old animals and assessed the ability of synapses to undergo long-term potentiation (LTP) after high-frequency tetanisation (100 Hz). Figure created with Biorender. B-C There was no signifcant difference in LTP between wild-type and hTMEM106B(+) animals. However, there was a significant decrease in baseline (pre-tetanus) paired-pulse ratio (P = 0.04), with hTMEM106B(+) animals exhibiting reduced paired-pulse facilitation. LTP; n = 11–14 brain slices/genotype. PPR; n = 15–16 brain slices/genotype. Data represented as mean ± SEM. T-test *, P < 0,05