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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Spectrum of γ-Secretase dysfunction as a unifying predictor of ADAD age at onset across PSEN1, PSEN2 and APP causal genes

Fig. 6

Linear correlations between clinical AAO and GSEC 'dysfunction' for PSEN1, PSEN2, and APP TMD variants. Linear correlations between clinical AAO and GSEC 'dysfunction' assessed by the Aβ (37 + 38 + 40)/(42 + 43) ratio for PSEN1 (black) and PSEN2 (blue), and the Aβ (37 + 38 + 40)/(42)* ratio for APP TMD (purple). The respective linear equations and 95% CIs are shown in the corresponding colours. Error bars represent SD for Aβ ratio (x-axis) and AAO (y-axis). 95% CIs for slopes (m) are PSEN1: 0.36 to 0.51; PSEN2: 0.14 to 0.52; APP: 0.33 to 0.64. 95% CIs for y-intercepts (b): PSEN1: 18 to 26; PSEN2: 45 to 54; APP: 23 to 36

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Molecular Neurodegeneration

ISSN: 1750-1326