Fig. 4
From: TREM2 and sTREM2 in Alzheimer’s disease: from mechanisms to therapies
Dynamic changes of sTREM2 across AD spectrum. (A) The levels of sTREM2 in CSF gradually increase throughout the AD continuum, correlating with microglial activation. This increase reaches its peak during the mild cognitive impairment (MCI) stage and subsequently plateaus or even declines in the dementia stage. (B) In elderly individuals, higher baseline CSF sTREM2 concentrations are associated with slower cognitive decline, particularly in memory and overall cognition. Furthermore, elevated sTREM2 levels correlate with a slower rate of hippocampal atrophy