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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Network analysis of the cerebrospinal fluid proteome reveals shared and unique differences between sporadic and familial forms of amyotrophic lateral sclerosis

Fig. 1

Experimental workflow with differential expression of ALS versus control CSF proteomes using TMT-MS. a. Schematic of experimental workflow to examine proteomic differences in cerebrospinal fluid (CSF) between subjects with ALS and controls. b-c. Volcano plots showing differential abundance profiles comparing control CSF (n = 44) to that from sALS (n = 35) and C9orf72 ALS (n = 10). Log2 fold change (x-axis) and one-way ANOVA with Benjamini–Hochberg corrected by disease -log10 p-values (y-axis). Note the commonly increased CSF proteins in patients with ALS such as NEFL, NEFM, and CHIT1. Proteins significantly (p < 0.05) increased in abundance are depicted in red, significantly decreased in blue, and neither in grey

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Molecular Neurodegeneration

ISSN: 1750-1326