Fig. 6

Asymptomatic individuals were distinct from symptomatic individuals with these differences indicating novel biology. a. Volcano plot showing differential abundance profiles comparing asymptomatic C9orf72 carriers (n = 59) and symptomatic C9orf72 carriers (n = 43). Differentially abundant proteins were mapped by module. The height of the bars represents the fraction of module member proteins that were differentially abundant. The bars are color coded by heatmap for average log₂ difference in abundance, where red represents an increase in abundance, and blue represents a decrease in abundance. b Asymptomatic SOD1 (n = 13) compared to symptomatic SOD1 carriers (n = 22). Differentially abundant proteins were also mapped by module. Log₂ fold change (x-axis) and one-way ANOVA with Benjamini–Hochberg corrected by disease -log10 p-values (y-axis). Proteins significantly (p < 0.05) increased in abundance are depicted in red, significantly decreased in blue, and neither in grey. c. Representative modules of groups outlined above stacked barplots are depicted restricted to subtypes depicted in volcano plots