Fig. 5
From: Molecular mechanisms and consequences of TDP-43 phosphorylation in neurodegeneration
Physiological cellular pathways of putative TDP-43 kinases. Schematic of eight key biological pathways that involve c-Abl, CDC7, CK1, CK2, IKKβ, MAPK14, MEK1, TTBK1 and/or TTBK2. These pathways include 1) circadian rhythm, 2) Wnt pathway, 3) ERK pathway, 4) NF-κB pathway, 5) p38 pathway, 6), microtubule dynamics, 7) PI3K/AKT/mTOR signalling, and 8) cell cycle. Figure constructed using biorender.com