Skip to main content

Table 2 Reported TDP-43 kinases

From: Molecular mechanisms and consequences of TDP-43 phosphorylation in neurodegeneration

Kinase

Description

Accession

pTDP-43 sites

In vitro assay

TDP-43 studies

Other neurodegeneration substrates

Expression and activity in primary TDP-43 proteinopathies

Expression and activity in other neurodegenerative diseases

c-Abl

Tyrosine-protein kinase c-Abl

P00519

Y43 [29]

[29]

[29]

α-synuclein, PD [281, 282]

Parkin, PD [283]

Tau, AD [284,285,286]

• ↑ ABL1 RNA in post-mortem sALS spinal motor neurons [149]

• ↑ c-Abl protein abundance in rNLS8 TDP-43 mouse model [143]

 

CDC7

Cell Division Cycle 7-related protein kinase

O00311

S409, S410 [14, 26]

[14, 15]

[14, 173]

   

CK1

Casein Kinase 1

P48729 (CK1α)

P48730 (CK1δ)

P49674 (CK1ε)

Q9HCP0 (CK1γ1)

P78368 (CK1γ2)

Q9Y6M4 (CK1γ3)

S2, Y4, T25, T88, S91, S92, T116, S183, S242, S254, S273, S292, S305, S342, S347, S350, S369, S375, S377, S379, S387, S389, S393, S395, S403, S404, S407, S409, S410 [11, 167]

[11, 34, 167, 173]

[16, 18, 19, 24, 171, 173, 279, 287]

APP-β, AD [168, 288]

α-synuclein, PD [171, 172]

Tau, AD [169,170,171]

• ↑ CSNK1D mRNA in post-mortem sALS spinal cord and frontal cortex [24]

• ↑ CSNK1E mRNA levels correlated with pTDP-43 in post-mortem sALS patient tissue [20]

• ↑ CK1δ protein abundance in rNLS8 TDP-43 mouse model [143]

• ↑ > 30-fold CK1δ in post-mortem AD hippocampus [144]

• ↑ CSNK1D mRNA in post-mortem AD hippocampus, amygdala, entorhinal cortex and midtemporal gyrus [142]

CK2

Casein Kinase 2

P68400 (CK2α)

P19784 (CK2α’)

P67860 (CK2β)

S379, S409, S410 [11]

[11]

[188]

APP-β, AD [168]

α-synuclein, PD [172, 178,179,180,181]

Tau, AD [182]

 

• ↓ CK2 activity in AD [289]

• ↑ CK2 in post-mortem AD hippocampus and temporal cortex [290]

IKKβ

Inhibitor of nuclear factor kappa-B kinase subunit beta

O14920

T8, S92, S180 [35]

[35]

[35]

TDP-43, ALS, FTD [35]

• ↑ abundance in post-mortem FTLD-TDP frontal and temporal cortex [193]

 

MAPK14

Mitogen-Activated Protein Kinase 14

Q16539

S292, S409, S410 [56]

[56]

[32]

Tau [291]

TDP-43 [56]

  

MEK1

Mitogen-Activated Protein Kinase Kinase

Q02750

T153/Y155 [32]

N/A

 

Tau

TDP-43 [32]

  

TTBK1

Tau Tubulin Kinase 1

Q5TCY1

S409, S410 [15, 22]

[15, 25]

[15, 22, 25, 30, 279]

APP-B, AD

α-synuclein, PD

Tau, AD [191, 192]

TDP-43, ALS, FTD [15, 22, 173]

• ↑ TTBK1 levels in ALS post-mortem motor cortex [25]

• ↑ TTBK1 in post-mortem FTLD-TDP/FTLD-tau brains [22]

• ↑ TTBK1 in rNLS8 TDP-43 mouse model [143]

• ↑ TTBK1 RNA in post-mortem FTLD-TDP-43 cerebellum [193]

• TTBK1 co-localize with pTDP-43 in ALS spinal cord aggregates [15]

• ↑TTBK1 in FTLD post-mortem frontal cortex [15]

 

TTBK2

Tau Tubulin Kinase 2

Q6IQ55

S409, S410 [15]

[15]

[15, 22]

TDP-43 [14, 15]

• ↑ TTBK2 in FTLD-TDP/FTLD-tau brains [22]

 
  1. Abbreviations: AD Alzheimer’s Disease, PD Parkinson’s Disease, ALS Amyotrophic Lateral Sclerosis, sALS sporadic ALS
Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326