Fig. 2
Protein level changes and correlations with biomarker measurements of protein clusters identified in TRIAD. Each segment of the circle represents one of the 12 protein clusters identified in the TRIAD cohort. The outer layer (layer 1) of each segment shows a plot of the cluster’s Eigenprotein values (first principal component of the cluster; z-scored) across tau-negative cognitively unimpaired controls (CTRL) and Braak stages I-VI, with each dot corresponding to an individual. The dashed line denotes the z-scored Eigenprotein value at z-score = 0. All remaining layers [2,3,4] are dedicated to correlations of the Eigenprotein value with relevant biomarker measurements in all TRIAD study participants. They show the Spearman ρ of correlations below the significance threshold P < 0.05 after Bonferroni correction. The second layer indicates correlations of the Eigenprotein value with tau PET SUVR in different brain regions, corresponding to the Braak stages I-VI. The third layer shows correlations of the Eigenprotein value with measurements of CSF total-tau, acquired by immunoassay, and tau peptides phosphorylated at different residues, acquired by mass spectrometry. Finally, the inner layer (layer 4) depicts correlations of the Eigenprotein value with CSF Aβ1-40, Aβ1-42, Aβ ratio and Aβ PET SUVR. Blue and red lines connecting the clusters represent correlations of corresponding Eigenprotein values. The presence of a red line indicates a correlation of ρ > 0.6 and P < 0.01, while the presence of a blue line shows a correlation of ρ < -0.6 and P < 0.01. Abbreviations: CTRL, control; PET, positron emission tomography; SUVR, Standardized Uptake Value Ratio