Fig. 7

Temporal profiles of protein clusters across Braak stages. Summary plot of loess-functions of protein clusters ‘core markers’ (magenta), ‘endolysosomal’ (green), ‘immune response’ (yellow), ‘metabolic’ (red), and ‘synapse & membrane’ (turquoise), as well as CSF Aβ-ratio (black), p-tau₁₈₁ (gray) and t-tau (steelblue) across controls (CTRL) and Braak stages in TRIAD. *The y-axis represents z-scored Eigenprotein values in the case of protein clusters and compressed z-scored abundances in the case of the core CSF biomarkers. Trajectories were additionally shifted in y-direction for better comparability. Thus, displayed fold-changes or baseline values are not comparable among protein clusters and core biomarkers