Fig. 2

Tau phosphorylation sites. Tau protein consists of 85 potential phosphorylation sites, some of which contribute to the physiological function of tau (green), while others have been implicated in the pathogenesis of tau (red). Certain sites have been described as contributing to both the physiological and pathological roles of tau (blue), while other phosphorylation sites have yet to be demonstrated in humans or have an unknown effect on the function of tau (grey). In CTE, consensus phosphorylation sites have been demonstrated to be present in post-mortem analysis and are implicated in driving tau pathogenicity (black asterisk). Created in BioRender