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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model

Fig. 3

Cell type composition analysis of wild-type and PS19 mice treated with vehicle or TPPU. (A) UMAP embedding of snRNA-seq data showing 84,226 cells from the hippocampi of 9.5-month-old WT_Veh, WT_TPPU, PS19_Veh and PS19_TPPU mice annotated by cell types. (B) Dot plot showing the expression of well-known maker genes for different cell types. (C) UMAP embedding of snRNA-seq data across different groups. (D) Stacked barplot showing cell type compositions with differences in DG and MG populations between PS19_Veh and PS19_TPPU highlighted. The bars are colored by their corresponding cell classes as labeled in (A). See also Figure S5

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Molecular Neurodegeneration

ISSN: 1750-1326